Published works

My publications on Google Scholar

• C Munk, E Mutt, V Isberg, LF Nikolajsen, JM Bibbe, T Flock, MA Hanson, RC Stevens, X Deupi, DE Gloriam. An online resource for GPCR structure determination and analysis.
  Nat Methods, 2019.

• IO Frandsen, MW Boesgaard, K Fidom, AS Hauser, V Isberg, H Bräuner-Osborne, P Wellendorph, DE Gloriam. Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.
  Sci Rep, 2017, 7, 4829.

• AC Nøhr, W Jespers, MA Shehata, L Floryan, V Isberg, KB Andersen, J Åqvist, H Gutiérrez-de-Terán, H Bräuner-Osborne, DE Gloriam. The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.
  Sci Rep, 2017, 7, 1128

• AC Nøhr, MA Shehata, AS Hauser, V Isberg, J Mokrosinski, IS Farooqi, DS Pedersen, DE Gloriam, H Bräuner-Osborne. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
  Neurochem Int, 2016, 102, 105-113.

• MA Shehata, AC Nøhr, D Lissa, C Bisig, V Isberg, KB Andersen, K Harpsøe, F Björkling, H Bräuner-Osborne, DE Gloriam. Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.
  Sci Rep, 2016, 6, 36681.

• C Munk, K Harpsøe, AS Hauser, V Isberg, DE Gloriam. Integrating structural and mutagenesis data to elucidate GPCR ligand binding.
  Curr Opin Pharmacol, 2016, 30, 51-58.

• C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, AS Hauser, P Kolb, AJ Bojarski, G Vriend, DE Gloriam. GPCRdb: the G protein-coupled receptor database – an introduction.
  Br J Pharmacol, 2016, 173, 2195-2207.

• V Isberg, S Mordalski, C Munk, K Rataj, K Harpsøe, AS Hauser, B Vroling, AJ Bojarski, G Vriend, DE Gloriam. GPCRdb: an information system for G protein-coupled receptors.
  Nucleic Acids Res, 2016, 44, D356-D364.

• K Harpsøe, V Isberg, BG Tehan, D Weiss, A Arsova, FH Marshall, H Bräuner-Osborne, DE Gloriam. Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.
  Sci Rep, 2015, 5, 13869

• PC Babbitt, PG Bagos, A Bairoch, A Bateman, A Chatonnet, MJ Chen, DJ Craik, RD Finn, D Gloriam, DH Haft, B Henrissat, GL Holliday, V Isberg, Q Kaas, D Landsman, N Lenfant, G Manning, N Nagano, N Srinivasan, C O’Donovan, KD Pruitt, R Sowdhamini, ND Rawlings, MH Saier Jr., JL Sharman, M Spedding, KD Tsirigos, A Vastermark, G Vriend. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat.
  Database, 2015, bav063.

• MA Shehata, HB Christensen, V Isberg, DS Pedersen, A Bender, H Bräuner-Osborne, DE Gloriam. Identification of the first surrogate agonists for the G protein-coupled receptor GPR132.
  RSC Adv, 2015, 5 , 48551-48557.

• V Isberg, C de Graaf, A Bortolato, V Cherezov, V Katritch, FH Marshall, S Mordalski, J-P Pin, RC Stevens, G Vriend, DE Gloriam. Generic GPCR residue numbers–aligning topology maps while minding the gaps.
  Trends Pharmacol Sci, 2015, 36, 22-31.

• KM Fidom, V Isberg, AS Hauser, S Mordalski, T Lehto, AJ Bojarski, DE Gloriam. A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors.
  Methods, 2015, 71, 104-112.

• I Kufareva, V Katritch, V Isberg and other paticipants, RC Stevens, R Abagyan. Advances in GPCR modeling evaluated by the GPCR dock 2013 assessment: meeting new challenges.
  Structure, 2014, 22, 1120-1139.

• V Isberg, KB Andersen, C Bisig, GPH Dietz, H Bräuner-Osborne, DE Gloriam. Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139.
  J Chem Inf Model, 2014, 54, 1553–1557.

• V Isberg, B Vroling, R van der Kant, K Li, G Vriend, DE Gloriam. GPCRDB: an information system for G protein-coupled receptors.
  Nucleic Acids Res, 2014, 42, D422-D425.

• V Isberg, J Paine, S Leth-Petersen, JL Kristensen, DE Gloriam. Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin 5- HT2 Receptors.
  PLoS ONE, 2013, 8, e78515.

• A Chalikiopoulos, S Thiele, M Malmgaard-Clausen, P Rydberg, V Isberg, T Ulven, TM Frimurer, MM Rosenkilde, DE Gloriam. Structure-activity relationships and identification of optimized CC-chemokine receptor CCR1, 5 and 8 metal-ion chelators.
  J Chem Inf Model, 2013, 53, 2863–2873.

• AA Jensen, N Plath, MHF Pedersen, V Isberg, J Krall, P Wellendorph, TB Stensbøl, DE Gloriam, P Krogsgaard-Larsen, B Frølund. Design, Synthesis, and Pharmacological Characterization of N- and O-Substituted 5,6,7,8-Tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol Analogues: Novel 5-HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties.
  J Med Chem, 2013, 56, 1211–1227.

• V Isberg, T Balle, T Sander, FS Jørgensen, DE Gloriam. G Protein- and Agonist-Bound Serotonin 5-HT(2A) Receptor Model Activated by Steered Molecular Dynamics Simulations.
  J Chem Inf Model, 2011, 51, 315–325.